MDMA and the brain


Currently MDMA studies are being fulfilled by a pharmaceutical company completed clinical trails of clinical usage of MDMA. Treatments are led by teams of doctors and therapists. Clients of the trial are monitored 24/7 during the treatment and the following day to ensure safety. 

Oftentimes with chronic trauma and stress exposure our brains can become chemically imbalanced. Often it is seen that chemicals like serotonin, dopamine and the adrenal glands are depleted. This can create moods such as Anxiety and Depression, ADHD, OCD, PTSD and more. 

MDMA, also known as ecstasy or Molly, is a psychoactive drug that affects the brain in various ways. Understanding how MDMA works in the brain can provide valuable insights into its effects and potential risks.

When consumed, MDMA primarily targets three neurotransmitters: serotonin, dopamine, and norepinephrine. Serotonin is responsible for regulating mood, emotions, and social behavior. MDMA increases serotonin levels by blocking its reuptake, leading to an accumulation of serotonin in the synaptic cleft. This flood of serotonin results in feelings of euphoria, increased empathy and sociability.

Additionally, MDMA also affects dopamine levels in the brain. Dopamine is associated with pleasure and reward pathways. By releasing dopamine into the synapses, MDMA intensifies pleasurable sensations and contributes to its recreational use. MDMA decreases activity in the left amygdala (associated with fear and trauma) which may allow patients to more openly discuss their memories in therapy.

Furthermore, norepinephrine is involved in regulating arousal and stress responses. MDMA stimulates the release of norepinephrine which can lead to increased energy levels and heightened awareness. MDMA also increases the release of oxytocin and prolactin (hormones associated with trust and bonding) as well as hormones that influence the HPA axis and stress response

It's important to note that while MDMA may induce positive effects on mood and social interaction temporarily; it can also have potential risks when used improperly or excessively. These risks include dehydration, overheating, cardiovascular complications as well as potential long-term effects on serotonin function. 

Understanding how MDMA works in the brain helps us appreciate both its potential therapeutic uses under controlled conditions as well as the importance of responsible use to mitigate any potential harm associated with this substance.

Because of the boost in all of these chemicals in the brain it is of the utmost importance that pre-care and post-care is setup with a medical team and therapeutic support. Just like chemicals go up, they can go down and often can be depleted after sessions leaving clients feeling lethargic, depressed, anxious, and in extreme cases suicidal . With the proper aftercare it can provide a sense of safety and support necessary for long lasting positive results from the treatment.